If you have some friends to play it with, Mario Party is always fun.
Mario Galaxy 2 topped the first if you enjoyed it enough for more.
Metroid Prime trilogy. I mean, its metroid, come on.
And if you like Ninja Gaiden and Metroid, then Metroid: Other M is a good choice.
Super Paper Mario is a good combo of light RPG and traditional mario.
Tales of Symphonia is one of the many anime-looking RPGs, but its lengthy and fun.
Kirby's Epic Yarn was surprisingly fun. Its not challenging by any means though.
As for a zelda game, Twilight Princess is the only one.
Is that Epic Mickey game out yet? I haven't heard anything about that one way or the other.