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You can play embered, just play offline and no invasions outside of NPC ones will happen.
Vit is basically useless IMO. Armor also makes a very minimal difference. Once I realized that, it was light/medium armor for life.
Well first couple times I made it to the boss of the 1st level. That's usually where I died as RNG wasn't with me and I had shit guns for the boss. Decided I like Marine the best for the accuracy so I never have to really swap from the side arm. I made it to the second level once (twin bullets = easy mode for me for some reason) but died shortly thereafter as I didn't have a ton of health left. I may play a bit more tonight, just depends on when I get off work as D3 season 6 starts tonight and I want to do that.
Is that different from the Doom thing they have now?