$160M doesn't cover marketing costs, which (despite common beliefs) studios actually do what to recoup. That being said, the $500M break even point did seem pretty high. The most recent article I read actually had the target at $450M so given the countries it was opening in this week the movie SHOULD break even.
Still, the movie did fucking awful here in the US. Not necessarily a nail in the coffin, but it's certainly something that will be taken into account if a sequel is considered.