Yep. With Mantle, a ton of mastery and three KC relics I lose more than 10k DPS from going AotB. Dire Stable also beats Way of the Cobra Single Target for a tiny amount (but since it's also better for anything that's not ST it's simply better all around).
From the latest SimulationCraft beta on me (Mantle, 2 Jaws of Thunder Relic, 1 Pack Leader Relic, Mastery everywhere, 865 iLvl, Hidden Satyr enchant, cheap enchants elsewhere, cheap gems, low iLvl pure stat trinkets, Artifact Level 26, YMMV):
- DS/Stomp/BF/KC: 349.5k
- DS/Stomp/BF/AotB: 332.4k
- DS/Stomp/OwtP/KC: 346.3k
- DS/DF/BS/AotB: 333.3k
- DS/DF/BF/KC: 353.4k
- BGH/Stomp/OwtP/KC: 349.1k
- BGH/Stomp/BF/KC: 347.2k
- BGH/DF/BF/KC: 355.6k
- BGH/DF/OwtP/KC: 353k
- BGH/DF/OwtP/AotB: 337.2k
- BGH/DF/BS/KC: 350k
- BGH/DF/BS/AotB: 339.1k
- Way/DF/OwtP/AotB: 331.1k
- Way/Stomp/BS/AotB: 339.9k
- Way/DF/BF/AotB: 339.3k
- Way/Stomp/BF/AotB: 338.7k
- Way/Stomp/BF/KC: 348.5k