Originally Posted by
Cunky
CoF is a great trinket regardless of whether you have vendetta relics, however, you should think about the bonus like this:
If your Vendetta cool down is 90 seconds then reducing the cool down by 5 seconds could be worded as: "Your attacks have a chance to reduce the cool down on vendetta by 5.5%."
If your CD on vendetta is only 66 seconds, the bonus would be: "Your attacks have a chance to reduce the cooldown on your vendetta by 7.6%"
So there is a great pairing between the relics and the trinket, but they are certainly not mandatory. I do believe, however, that you should let other classes take it if you're not going to maximize its utility.