First game, I couldn't do anything. I was early in the draft when someone decided they'd rather AFK when the other team took the hero they wanted. Everyone just went assassin after that, and there was nothing I could do about it.
Second game, again nothing I could do. Our Lucio went with the other healing talent at 16. When their Malf does double the healing of your Lucio, without Tranq, you can't really do anything. Flanking that frontline is not an option on ToD either when you're busy contesting potentially game-ending altars.
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Couldn't get past them. Any time I went near any of them I got instantly focused. The only reason I didn't die was because I picked Force Armor at level 1.