I generally can never get into D&D games like Baldur's Gate. There's just something about the combat system that makes it impossible for me to get into it. It's a shame because I really enjoyed Planescape: Torment while it lasted, but I just can't do it.
Also:
Dark Souls. Everyone hates when an RPG has a long, unskippable cutscene before a difficult boss. It was like that for me, except for every half a minute of getting my ass whooped by a boss, I had to go through 15 minutes (might be exaggerated) of killing the same skeletons over and over again. I beat the first boss (the minotaur on the bridge) and game said "Victory Achieved" and I called it there. Might've tried more if bonfires were closer to the bosses, but nope.
Wouldn't say I don't mind difficulty, because I do, but I found some skeletons near the first campfire that were apparently way beyond what I should be fighting yet. And I had no problem coming at them until I killed them simply because it wasn't far to get back there.
Dragon's Dogma. It looked like something right up my alley, but somewhere between the story that never caught my attention in the first place, much less keep it; mission boards filled with "kill x things" and every other quest sending me to the other end of the planet; I found it boring and quit.
Overwatch. I do actually like it and find nothing really wrong with the game itself. It's just that I'm so bad at it I feel bad playing it. Doesn't help when after an awful performance I still get majority of the gold medals on my team...
A mention to Divinity: Original Sin. I mostly stopped because friend I was playing with decided to call it quits, but one of the reasons we did was because half the time it felt like we're fighting the UI rather than the actual enemies. Inaccurate healthbars, debuff timers, aoe range circles and moving models that frequently cause misclicking and moving instead of attack. There were some elemental enemies in particular where I had to time the click just right to hit it, because they kept doing backflips. Or frontflips. They were floating rocks essentially. Really?