On queen hm(shandra manaya) she will stand up every 50 sec and do 3 sets of debuffs, 1 in melee, in a bit further out, and 1 in the rest of the room, you need 1 person to take each debuff, and you take 40k damage(can't be mitigated by anything but shield buffs) and 8.5k every few sec for the rest of the fight where you will have the debuff. These debuffs also have to be rotated, so if you took melee first then you need to take middle next, and then outer after that, then repeat.
It's a pretty interesting fight, and i still enjoy it even after having killed it over 200 times. On the individual skill level, I'd rate the fight on par with the hardest of wow fights, in regards to staying alive and not causing a wipe anyway. The dps requirements are not huge if you are in abyss/regent gear, and quite a joke if you're in visionmaker. WHen we first did it in tier 13 equipment it was pretty damn tough though, as it couldn't be done the easy way with bursting from 30%.