There is enough to keep you interested, but you'll want to be in an established corp if you want to do it all. There's lots of different kinds of PVE, and highsec missions is such a small fraction of it that you won't continue playing if that is all you do. It might be fun for 2-3 months, but that will be it. Nullsec has the same basic missions with much better rewards. Wormhole space has advanced AI that takes multiple people to do. Both Nullsec and WH space are lawless, though, and you might be susceptible to being ganked if you aren't careful. Being careful in Nullsec is very easy and will eliminate just about all danger. The only way to not get ganked in WH space is to be cloaked up at a safe spot. Anywhere else, you can be ganked no matter how careful you are. Of course, you'll probably also be with a few other people, so you typically don't have to worry about 1 roaming ganker.
Also, RIP Jukebox