I've noticed a new trend beginning in "The One Thread" so why not dedicate a thread to this discussion overall? Maybe this will help people think of different/better ways to bind their keys to make things easier.
For me, I use the Razer Naga. I've used it with WoW, with CoH, with LoL, with SC2... with every game I ever play. As such, I keep a unified set-up for my Naga keypad that simply inputs the 1 through = row on my keyboard. (so basically it actually inputs 1-12). Normally I use modifier keys, so hopefully that's added to GW2 in the next beta.
My binds, with the Naga in mind:
Movement: Default WASD + QE
1-0: Default 1-0 (used with Naga obviously)
Weapon swap: mouse5
F1-F4 profession keys: Rebound to Z through V
Swim down: Shift key (Was originally unassigned)
So I didn't do anything too special.