This game is going to be amazing. I finally got around to watching the video from last Blizzcon and I love pretty much every point they discussed in regards to MOBAs. Getting rid of last hitting, making team kills "takedowns" instead of whoever got last hit on the kill, the tower changes, boss monsters on maps helping you in lane instead of just giving you a boring buff, etc.
This is one of the things I love about Blizzard, they really can look at ideas in different ways and make something unique. As a longtime MOBA player I'm super excited for this.
p.s. Blizzard & Valve just came to an agreement and the new game will be called Blizzard All Stars instead of Blizzard DOTA.