Nearly always a bad thing because people don't understand the space those animals need and their dietary needs... not to mention if they don't hunt you have to come up with some way to exercise their minds and bodies. It's not something most people can handle.
There are a few wolf-dog hybrids around though they are illegal in many places... I actually used to know someone who had one. Was a great animal, but occasionally too much of the wolf instinct came through.
I'm not even sure horses and zebras can mate actually....
I've seen a documentary about this orangutan that was all cute, but then it became a teenager and got all horny and violent.
So last year at a Renaissance Faire I managed to get a picture of me holding a European Eagle Owl. This year I am really hoping I can get a picture next to the Liger. I doubt they will let me get close to him though.