The UI in GW2 is clean and gets the job done. Even so I'd still love to have the ability to move and resize some of the elements to fit my viewing preferences. I play on a 2560x1600 monitor so even the LARGER scale setting for the UI leaves Conditions somewhat hard to read.
All I really want is the ability to move and/or resize the Unit Frames and the Condition frames for myself and the Target. I tend to like a HUD style in my games so I can get the info I want quickly. That would mean having Self and Target Conditions slightly larger and more centered on my screen as well as moving my Unit Frame and the Target Unit Frame to similar positions.