I think you're being shortsighted in making blanket statements that the audiences are "completely different". The several thousand pilot battles in EVE are few and far between, and with time-dilation you aren't so much participating as watching a slideshow. It's also not clear yet how the instancing works as you've mentioned. Yes a single instance may only be 60 people, but if there are seamless transitions to other instances, an entire theater of action might encompass hundreds of people.
And for people who have the space-sim/MMO itch -- EVE has been pretty much the only game in town. You can't convince me there aren't a chunk of people in EVE that are only sticking with it because it's good enough for them now, but wouldn't love to play something that's more involved than "stare at dot on map and press F1-F6, maximize transversal and yawn". Industry is also severely short-changed in EVE due to various factors, chiefly the devs belief in small-gang roaming and risk vs. reward for mining is shit, ore respawn rates are slow, etc.