If you use 3 monitors, such as in an eyefinity set up, or the nvidia eqiv. I'd like to see how you set it up, failing that, lets discuss.
I usually have just my unit frame and target, tot, focus, actionbars and buffs/debuffs on the main screen (raid frames if on a heals), left screen holds chat box, party frame, (raid frames if I am not heals). Right screen has minimap, menu bar, crafting and non combat actionbars.
So? How do you guys roll?