the two games that made me laugh the most are by far saint's row 2 and the Uncharted series on ps3.
Saint's Row was just hilarious because i made my character look like a really fat guy with a bowlershat, elvis hair and an english accent. oh and he also had a very feminine walk. it just so so funny to play as that character being a gang boss and all.
Uncharted has amazing actors and the jokes are honestly funny and well written. Great writers!