Its not the focus of the game, rather its a very small part, but it has been done the absolute best in any video game I've ever played. The love between Jackie and Jenny in The Darkness was presented in a very real fashion that I could believe.
Xothic - Prot Paladin - Expired at the end of 5.1, returned start of 5.4, left again. Bleh.
How has ICO not been listed yet.
No love for FemShep/Garrus? For shame. Absolutely support the Morrigan romance, one of the strongest female characters ever seen in a game. And Garrus can ...calibrate you.
Now, I doubt that anyone here played (or still remembers) Bulletstorm, but General Sarrano and the Protagonist have the best married couple dialogue.
Anduin and Varian.
In all honesty though, probably Laharl and Flonne. He raided Heaven for the girl, that is pretty ballsy. (Disgaea)
SS Link and Zelda and Shadow of the Colossus. Those final moments in that game, after being shot and possesed by darkness, you still struggle towards the girl
A wise man once said: "Does it matter what religion you are?
we are here to connect each other people in the world ... through MUSIC"