At one mob, I run my single target rotation. I never once press fan or tempest.
At one hundred mobs, I believe I run nothing but fans and tempests. If I have so much energy and combo points that I will be spamming tempests, I'll throw an envenom to get the buff and continue.
But what do I do at three mobs? Four? Six? Eight?
When do I keep a slice running, and at how many is that not worth it? Is it ever better to use envenom with full energy and then spam fan during envenom buff? When should I multi-rupture? How many ruptures, and how big should each one be?
Do we have definitive answers yet? I'm doing fine running with intuition, but it would be great to know!