I've got two GTX 690s in a Quad SLI configuration, accompanied by an i7-3820 at 4.5 GHz, 8 GB of DDR3 at ~2000 MHz, an X79 motherboard, and a LEPA 1600W PSU.
Compatibility: NVIDIA has been very good about providing SLI support on a lot of games on the market, but how well the GPUs scale and if multi-GPU rendering is even supported (or effective) is more to do with the game. Battlefield 3, for example, enjoys very high performance scaling with SLI because it was developed with multiple GPUs in mind in addition to the fact that there are a ton of visual details on screen which allow the presence of additional GPUs to be more noticeable. World of Warcraft does support SLI and performance gains can be seen with it, but games of this nature share a common problem with older games and those that aren't visually intensive: a lot of the time, the CPU usually ends up with more work to do than the GPUs, meaning performance gains with SLI may be marginal if they're observable at all. In that case, it won't matter how many GPUs you add into your system; your CPU is still going to be more determinant of performance. The point where this occurs depends on your system specs and the visual settings of the game, and so it varies from game to game and system to system. It's also important to keep in mind that a better frame rate doesn't necessarily always occur at the point of highest GPU scaling - running with 1x multisampling and getting 180 FPS but low SLI scaling is a better position to be in (for raw performance) compared to 4x multisampling and seeing high scaling but at 130 FPS.
Overclocking: The 690s handle themselves very well beyond stock frequencies, but what ends up being stable for yours isn't necessarily going to be the same for mine, for example. One of my 690s overclocks better than the other, and when running SLI, you always need to limit your OC to the lowest common denominator if you insist on forcing synchronized frequencies. (This isn't required, but some people complain of instability when running them asynchronously overclocked. Your mileage may vary.) That stuff aside, both of mine can comfortably run at 135/+100/+220 (power target/GPU offset/RAM offset.) I'd suggest running the Unigine Heaven demo benchmark at the highest settings five or six times to roughly ensure stability at a particular clock speed.
Temperatures: You'd do well to watch the GPU temperatures, especially if you're gonna be overclocking. Set up a fan curve profile through EVGA Precision or MSI Afterburner to make sure you don't end up in a bad spot. Mine idle around 30C and reach their peak at around 82C, at which point the fans have long been howling at their fastest speeds.
My Heaven results:
http://i.imgur.com/UQx9m.jpg
Lemme know if you have any specific questions.