Originally Posted by
Kirroth
It comes down to if you have Grim of Supremacy or Grim of Sacrifice.
As Destro, the stat that most effectively boosts your demon is Haste. So with Grim of Sup making your demon a major part of your DPS you stack Haste to buff your pet. This also lets you cast spells faster which generates Embers faster which means more total Chaos Bolts cast over the duration of an encounter.
However, if you take Grim of Sac and don't have a demon, Haste loses some of its punch. Instead you're better off stacking Mastery to make your fewer Chaos Bolts hit harder. Combined with the Grim of Sac boost to Chaos Bolts you get some truly monster nukes, though you hit more lightly in between them.
I believe the theorycraft is that a Sac/Mastery build comes out ahead when you can cleave your monster Chaos Bolts with Havoc to double their effectiveness, while a Sup/Haste build is slightly ahead on single target. However the margin of difference is fairly small and can be ignored unless you're pushing heroic raid kills. And even then, the difference between Haste and Mastery isn't an enormous one. That trinket is very good no matter which way you go because you can control when it activates and line it up with multiple Chaos Bolts.