I'm mentally seeing assassination ahead if we need to help kill a series of adds at range (unlikely but possible - shuriken toss/mobswap to apply poisons at range), or with lots of target swapping, which is always likely. If nothing changes, I'd expect to see combat ahead in 4p on single target and cleave, and assassination reigning supreme for large target swap or partially ranged fights. Sub looks, to me, like it would be ahead on patchwerk before the 4p bonus hits combat, but... the 4p bonus hits combat.