Now this is where the confusion lies: If it's red, and the new DoT would be weaker than the current DoT, do I wait for that DoT to fall off completely (unless I get a proc or something that changes it to higher before it runs out), pretend Pandemic doesn't exist, and only refresh the DoT when it's gone, or refresh it like at 1s left, or something else? It seems like letting the DoT fall off completely (especially in the case of Agony) would be a huge DPS loss, but wouldn't it also be a DPS loss to refresh it with a weaker version without letting the stronger version get all of its ticks in? I think I've been screwing myself so far because I have WeakAuras set up to show each DoT icon and have it show a large flashing icon when each DoT <= 50% of its max duration, and I've been reapplying it almost immediately when I see that to avoid it falling off completely and give it a longer duration; from reading a bit more guides this seems to be the wrong thing to do, even with Pandemic?