I have seen this on forums for a number of other classes and thought it would be good to hear from Rogues.
Blizzard has said we have too many abilities and so it would be good to hear what people would be willing to lose (assume you have to choose 5). For me (PvE Rogue, if I had to lose 5 abilities):
Talent based abilities - Deadly Throw and Combat, and Throw/Shuriken Toss
Pick Lock (although they would have to make lockboxes open some other way).
I deliberately do not count Pickpocket, Shadow Walk, Shroud of Concealment as I do not have those bound normally.