I'm trying to develop a new RP element while I play, and I think the interface gets in the way. Basically, I want the Domino's faded opacity on 0% for everything. I can do my bars, menu and bags, but my character profile, map and chat box still get in the way.
Another option is to use Kong UI Hider. It hasn't been updated in a long while, but still works fairly well. You can hide anything but still mouse over it to have it show, or set specific conditions. Very handy for creating a minimalistic UI.