The problem is that I am a klutz. If I were a Dungeons and Dragons character I would have a Dex score of 3. Every time I try to use Shift-Alt-Ctrl and then another key I get the WoW equivalent of a D&D Critical Miss and my Hunter does some dance emote and dies horribly.
I honestly do not know how you youngsters can use your pinkies and thumbs to quickly and efficiently hit modified keys while still strafing, running, and moving. I pretty much have to stop, look at my keyboard, press ALT, contort my hand, stretch to the E, and then either pop a brain aneurysm or watch my own pet eat my Hunter in frustration and embarrassment.
I think I just need to develop muscle memory. I am going to bind Shift-E, Shift-F, and Shift-C for now and try that out. Those seem to be easiest for my hand. Maybe in a year or two I'll get the hang of it.
Thanks again to everyone - this has been an awesome discussion. I did not know forums could be polite and helpful in 2014. Miracles never cease