Destro is the God-king of warlock DPS specs for challenge modes. Fire and brimstone + Havoc CBs/Shadowburns... just nasty.
As far as specific talents (incoming flame from warlock mains), I'd recommend GoSup for trash (use observer) and if you can manage switch to GoSac for bosses, then back to GoSup for trash. If you're gonna run with just one, GoSup is better overall (as GoSac doesnt affect Fire and Brimstone).
As far as gearing goes, try to get as many sockets on your gear as possible (allowing you to stack stats of your preference) and itemize for mastery > haste > crit. Be sure you're 15% hit capped for CMs.
I could try to explain the playstyle, but if you are familiar with the intricacies of destro warlock, I needn't take the time.
Also, tier set bonuses and legendary cloak/gem procs DO NOT work in challenge modes.