Originally Posted by
-Doko-
Barkskin for anything that might deal ~50% of your health, bear wall for anything that you can predict, keep bear stand or renewal in reserve for spikes unless you know for sure you are gonna need it.
When something like locust at the end of paragons is hitting you for 500-700k simply make sure to weave barkskin inbetween metagem procs to prevent spikes (unless you are going to blow bear wall soon in which case stack them, bear wall -> barkskin again if meta is not up)