Yes. The easiest way is to check your tooltip values while switching a piece of gear, enchant or gem. You will need to multiply by the crit and MS coefficient though. The crit coefficient is 1+(character sheet crit % value, * 2 for Living Seed enabled heals and * 0 for glyphed Regrowth), for Multistrike it's 1+(character sheet MS % value*1.6).
The not so easy way is to jump into Hamlet's HealerCalcs, or start spreadsheeting on your own.
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500 Mastery is 500/88=5.7 percentage point of added Mastery, if you already have 20% Mastery it's 4.7% added healing. For 12 seconds. Not overwhelming.
Some of the top gold runs on Warcraftlogs use Mark of the Shattered Hand. Atleast for some fights - which is an idea, since we can switch weapons during combat, we can have 1 of each enchant type and swap in the spirit one whenever it's needed.