I've slowly worked on cutting additional programs out of the loop but it isn't helping. I knocked it down to basically the game + obs (streaming software) and I wasn't getting attacked, but further testing will tell if that's a fix or when I got to that stage the DoS'er was AFK / in bed.
I've also run more scans, this time with Norton (provided by my ISP to all their subscribers) and it found nothing as well.
Thusfar I've run: Avira, AVG, Norton, RKill, RogueKiller, Spybot: Search & Destroy, Malwarebytes, Microsoft Security Essentials, and AdwCleaner. No detections.
However, just to be on the safe side, if it happens again I'm prepared to do a 100% clean install of windows and go from there. It should be noted that my Windows is 100% up to date as well.