Terrorbound nexus is probably worth switching to on trash over something like appendages which is pretty shitty on aoe for example. Terrorbound is pretty beastmode for big groups
Let's say I'm in a maw M+ i'll use terrorbound nexus with the windscar whetstone if we are pulling everything up to the boss....Makes for massive aoe burst in the millions.
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Trinket use is going to differ from dungeon to dungeon,can be pull specific and also depend on your group comp and also how high the M+ is imo I find myself swapping trinkets constantly during M+ but maybe i'm just a tryhard.