From my testing after getting an Icon of Rot on my alt mage, Plaguehive and Sinew for sure.
I don't think there's a worse trinket out there than Icon of Rot. Did around 1.2% of my damage tops, which is half of what my 850 shock baton did. And this was over three 5 minute rotations.
Sometimes it even missed the target when it procced despite me standing 10 feet away, lined up perfectly.