if you follow what Grmmppff says, I would on wave 3 cast the hots before tranq, because that way your hots actually get to tick and your tranq benefits from your mastery. I got it using the scheme described above in the thread were you tranq on wave 2 and just spot heal 2 guys in wave 3. Like that no one came through for me and I had a very clean transition into the boss.
As a usual clique/grid healer I also had a lot of trouble adapting to targeting the mobs on Stage 5. The method I ended up using was binding rejuv/wild growth/regrowth to shift + q/w/e(i have 1-4 dedicated to efflo and cooldowns). The actual buttons do not matter much so long as they are convenient for you. This gave me quick access to the only spells you need. I just sat right near the boss and held shift down and clicked and cast as fast as I could. I was completely immobile doing this but that is not an issue here.
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