Not out of desperation (as in "oh my god I can't take it anymore") but in a rational way as in there is nothing more for me in this "life".
I'm 40, I live alone, I'm unemployed and can't work anywhere since I will suffer anxiety and panic attacks just at the simple thought of doing anything at all.
My family despises me, I have no friends (they all left since they can't be bothered by someone like me) and even video games which have been my passion since I was 10 are no longer fun for me (I get bothered after a couple of minutes playing my favorite games).
And before you say it... I've been in therapy and medicated for more than 20 years now and nothing changed, at least not for the better.
And that's it, as you can see I'm thinking rationally and not whining, this is what my "life" is and as you can see, there is nothing in it for me.