Originally Posted by
Riboe
Ideefixer, I might have misunderstood you, but the solution to your question is simple (If I have understood you correctly, that is), but mouseover macros might do the trick. Basically, it's mouse over a target, click button on keyboard and it will cast the spell on whoever your mouse is hovering over.
EDIT: Clique on the other hand is to only use your mouse to cast spells. You bind your spells to various buttons on your mouse, then mouse over a target and click a mouse-button to cast a spell. It won't target whoever you're mousing over, but just cast the spell instead, which is almost the same as mouseover macros.
Instead of using your keyboard to click your spell, you use your mouse.