You don't need tons of useless information on the screen to play properly. I could have removed half of the information that was in my UI and still play the game doing hard-modes; the only reason there was quite a bit of information was because when I released it people wanted me to display more things.
I could quite easily raid with a player, target and ToT frame with a DBM timer and nothing else on the screen. I look at the game world itself more than anything. The only time I look at the UI is for a quick, which is usually less than a second.