For example your healing meters border is thicker then the other 1px borders. Same for your reputation bar. And if you moved your water shield bars a pixel lower you would get rid of the ugly 2 px frame between them and your UF too. Also, why not make it as big as your mana bar? Your boss frame seems a bit randomly placed since it isn't really aligned to anything.
Your debuffs also seem a bit unreliable to use in the middle of a fight, though I guess that's personal preference. Oh and what's that ToT or Focus frame doing there?
But all in all you're getting there quite well.
Oh, your target buffs or whatever, it is is a pixel to far to the right.