Few suggestions: Your BigWigs(?) has a different font so you're rocking 3 fonts in your ui. I'd change that, you can modify your BigWigs to suit the rest of your ui.
Your actionbars got pixel icons, but your weakauras don't. I'd use cleanicons to sort that out, and remove the zoom from the icons so you can get nice crisp borders.
If your minimap addon can't handle it, I'd get another addon to only show the LFR button on mouseover or with a modifier since it looks very much out of place (SexyMap for instance).
And lastly, you have scrolling combat text all the way down to the right corner, pretty much as far away from your raidframes as possible. Do you really need to show it at all then?