Well, a clicker always uses the mouse, right? It looks like this one uses the keyb on the keys near WASD and the mouse for the things to the right. Whats the problem? Looks like a sort of "multitasking if you ask me... ;D
And it looks like the addons are in the movie info:
Addons:
DHUD for 3.0 (NOT dhud3) [around my kitty]
Power auras [savage roar timer +++. Use the one on wowinterface!]
CooldownTimers3 - I dont use these anymore. I use OmniCC + OmniCC_shine instead of these now.
TitanPanel [the top panel]
Bartender 3 or 4. [the bars]
Xperl [top left frames + debuffs]