Well, since the whole Twitch Plays Pokémon hype died down, it appears that some creative genius has come up with an entirely new way of playing Pokémon, and streaming it on Twitch...
Yep, they've set up a camera on their fishbowl, and are tracking their betta fish's every move as it swims around it's bowl. Overlaid in front of the fishbowl is a 3x3 grid, with each segment of the grid assigned to a button, controlling the Pokémon game.
The fish is named Grayson Hopper, and according to the twitch page has been playing for around 135 hours. They're playing Pokémon Red, and so far Grayson has acquired his first Pokemon, a Charmander named AAAABBK, and defeated his first opponent, the rival's Squirtle, completely unassisted, and is currently working on making it out of Pallet Town.
Currently has nearly 20,000 viewers.