Regularish setup on mine (I7 on Asrock extreme 3, 8GB Ram, 80GB SSD) with a couple of notable bits:
GTX480: On par for most things with a 570, runs hotter, takes a bit more juice but often a lot cheaper
Dell Perc 5/i: Hardware raid 5 with a decent amount of fairly fast drives (5 1TB F3's) means bulk storage that can keep up with an average SSD for throughput
Asus Xonar: Can't rate these cards highly enough, forget 5.1 headsets etc etc, a GOOD pair of headphones + dolby headphone is much better. I still use a cheap headset but will be upgrading at some point.