Heroic Leaden Despair + Impetuous Query are one of the best combos for trinkets pre-raiding. Possibly only beaten out Heroic Leaden Despair + Heroic Tia's Grace (Yes, I know it's AGI, but that's 1% dodge on top of the silly amount of mastery).
As to the HP vs Avoidance question, I'd say avoidance after you're at around 140k unbuffed. You don't want to be a mana sponge.