For me it's
4. Heroes of Might and Magic 6: Sort of new to the series, played 5 & enjoyed it, so I'm looking forward to the new one!
3. Dungeon Siege 3: One of the more enjoyable Diablo clones IMO, interested in seeing what Square Enix does with it.
2. Dragon Age 2: Loved the first one, didn't love its expansion. Here's to hoping that the gameplay is still as fun as the original despite core changes.
1. Diablo 3: Played the "hell" out of 1 and 2, I am REALLY hoping this game makes the leaked Q4 2011 time line.
I noticed a few posts down that Elder Scrolls 5 is due out next year as well. Never played Morrowind or its predecessors, but I did play Oblivion and enjoyed it... until I discovered 100% chameleon, but the dark brotherhood quest line was amazing. Anyway probably need more than a trailer for it to make my list. What are you guys looking forward to?