I recently extended my trinket library with Heart of Ignacious (HoI), while using Vibrant Alchemist Stone (VAS) & Darkmoon: Volcano (D:V) before. Easy comparison link <= I applied some reforging and gemming
I am not 100% sure what is the best combination, when specced for Destruction or Afflicition, but I think it will be HoI and D:V. Can anyone confirm or deny this? I haven't got the time yet to setup some simulations.
According to the EJ, VAS and D:V are the way to go for either spec. I would run the sims anyways if you want to be especially sure, since the results may vary character to character.