I'll be the first to admit it is a semi CFD (Clusterfuck Deluxe), but I like having all the pertinent information in my peripheral vision, or just a slight glance away.
I do want to replace the raid frames in the upper left corner though, I don't like them taking up that much room anymore.
Try Grid for raidframes, you can scale them down nicely. And this 'Healers Have To Die' announcer thing would drive me nuts.
I use Grid for my shammy, and never really thought about using it for raid frames until I saw others using it in this thread.
And the Healers Have To Die announce did drive me nuts, I finally figured out how to shut off notifications, I only like it for PvP because it puts a big red cross over healers.
This was when i was still muti at the start of cata but its much cleaner now, basic layout is still same, i need to keep it simple coz of my crap computer.