Well.. it takes a bit of thinking what your main heat sources are and the directing more flow over these areas... thermodynamics bear is looking at you...
Heat rises so its better to have exhausts where this is going to flow
but dont listen to me I take the side panels off and just let my heat radiate away........ water cooling is the bomb tho
as for pressure levels... well fans are not that powerfull so I doubt you can create a vacume or a condenced air by just fan means thats gonna make much difference.
but like i say I have done away with fans totally... they suck and are noisy