Maybe. It's a very specific card that will only truly benefit people looking to play games and do CUDA-based computing. It might find a spot in the higher end builds, but I'm doubtful towards it replacing the dual GTX 690 in the top build. Will have to wait for benchmarks to see how 3-way SLI Titans compare to 4-way SLI GTX 690s to make that judgement. I do think the GTX 680 or perhaps even the GTX 670 with a proper PCB stand tall in SLI configuration compared to a Titan. Benchmarks will show if I'm right.
At $1000 it isn't easy to justify its place in any build as they are after all gaming (and price/performance) focused.