So, after more or less disregarding this talent in 5.0-5.1 (largely due to the lack of dangerous DOT mechanics in that tier), I've found myself running the new Hand of Purity a LARGE majority of the time in 5.2/ToT. Granted, we're only through Durumu (or will be tonight, stupid DC-boss killed us last night!), but I've began a love affair with this spell, and wanted to share my uses for it as well as get some feedback or other ideas on how to use/abuse it.
JinRohk: Used UbS/unglyphed DivProt here, but the fight was such a roflstomp it doesn't matter. Maybe heroic will be different, but I imagine that UbS with 40%DivProt is still pretty good.
Horridon: HoPur could be useful if your healer comp struggles with dispels or dealing with damage. I found myself tossing out Cleanse's for the poison trolls, and ended up running Clemency here for extra HoSac/freedoms, but largely this seems to be preference.
Council: Personally ran clemency here for Sac's on DPS during the reflect dmg guy, and freedoms on other DPS. Not much DOT here.
Tortos: UbS is great for tanking bats, not really anything else useful, but a fun fight.
Maegara: Holy hell, HoPur is amazing here. We did blue, red, blue, red, blue, red, blue (which meant that I was going from green to red, and it was fucking painful). 40% DivProt and HoPur is MADE for this fight. This basically renders the sear flesh to a tickle, and can use 2x per flaming head.
JiKun: HoPur makes you a slime-soaking machine. Sure, it's super useful for the stacking bleed while tanking boss, but dear lord, you can soak 5+ puddles while not tanking with HoPur and clear up TONS of real estate.
Durumu: Still on the fence between UbS and HoPur. In normal, the damage doesn't seem high enough to warrant HoPur for Arterial Cut, so I;ve been using UbS just for the extra cooldown, but I suspect either works well. Now that there is a passive 10% dmg redux on HoPur, it's likely the same overall mitigation as 20 sec off of a 20/20% or 40% cooldown.
So, just wanted to offer that PSA, esp for folks on Maegara and JiKun.
Any other creative or OP uses for HoPur so far?