Originally Posted by
Occar
Don't listen to this person. Always sim yourself, but the general trend is, unless you have some really poor off pieces that force you to use the ring, Raddon's/Anger is very likely to be your best legendary pair in all scenarios regardless of target count. Sims aren't the only evidence of this. If you check the DPS stats for a given legendary on something purely single target like Garothi via warcraft logs, you will see that builds with Raddon's equipped have 70k dps better performance at 75th %ile on heroic. It's also better via the mythic stats, but if you're asking this question, I'm going to assume you aren't doing mythic. Also, the 2pc alone isn't very good. Don't replace T20 with it, and don't try to use the bonus with T20
tl;dr: Sim yourself, but you'll probably find that helm is the better choice. Use 4pc only