I think Blizzard won't let us kill any major character. Jaina will most likely avoid death as it makes sense, she might get her sweet staff broken?
Rastakhan probably dies but I think he will sacrifice himself (again) to gain power in order to push the Alliance back.
I like raids in city environments. Boralus is one of my favorite dungeons as an Alliance player. SoO was nice concept wise but I didn't like the aesthetics of Orgrimmar. Zuldazar will make a nice troll raid.