I would overlook a whole lot before reaching the point I can't enjoy someone's work anymore. Thinking about it I can see two major criteria for dumping someone: If it's personal or if it impacts their work. Nothing's been personal so far, since none of the creators I follow know me nor do I have characteristics I'm sensitive about.
Someone mentioned Cryaotic. I know of him, but haven't really followed his content, just remember enjoying a series about Resident Evil 6 he did with Jesse Cox years ago. Because that's the level of shits I give I don't really care what he's done, might as well watch some of his videos if Youtube suggests them to me. But if, say, Markiplier or Game Grumps did something I'd be concerned, since I like their content quite a lot and feel I have a pretty good grasp on what they're like as people; their personas, beyond the bits they do, is part of the package and therefore essential to remain untarnished. Allegations of their misdeeds would first have to be proven beyond doubt before I'd write them off, of course. If they're not then it's like nothing happened, e.g. I enjoy ProJared's content the same as before.
Then there's the likes of Kevin Spacey. A damn fine actor, totally made House of Cards. Looks to be the kind of person I wouldn't care to hang out with, but I'd love to see more movies and shows from him. As an actor who portrays people separate from himself it doesn't matter as much what he's like. Youtubers do bits, but they are essentially portraying a version of themselves, which is why it matters what they're actually like.
There are creators I might have issues with, but not quite enough to dump them. One example is the guy behind Least I Could Do webcomic. At some point the comic became political in a very preachy way, which is annoying af, but since I still check it out weekly I can't say it's lost what I like about it. The core is still there, it's just that the creator's political views are pushed at people in quite a hostile manner. In this case they differ from mine to a degree, but I can't imagine I'd like the main character's preaching any more if it toed my line; it's still preaching rather than what makes the comic entertaining. Game Grumps sometimes discuss issues while they play a game, but they mostly have the good sense to be neutral or at least non-judgmental, suggesting they understand things can be nuanced. Their platform is also a better fit for such things than a cartoony webcomic.
So yeah, my beef with creator misdeeds is really about how much it affects their work. Played through Shadow Complex some years ago, fully aware of its creator's homophobic statements. Don't care, the game didn't feel impacted by it at all.